Endocrine Abstracts

Introduction: The beneficial effect of GH replacement on bone in AGHD patients is mediated by improvements in target organ sensitivity to PTH and phosphocalcium metabolism. In aging women with established osteoporosis, GH and IGF-1 concentrations are lower and administration of GH has been shown to increase bone turnover and BMD, but the mechanisms remain unclear.Methods: Fourteen postmenopausal women (63.4±2.1 years; mean BMD T score ± ...

Leptin stimulates osteoblastic cell proliferation, differentiation and mineralisation and inhibits osteoclast generation; leptin secretion and bone turnover are altered in adult growth hormone deficiency, a condition associated with osteoporosis. The aim of this study was to investigate leptin circadian rhythm and its association with bone turnover in untreated AGHD and following growth hormone replacement (GHR).We sampled peripheral venous blood at half...

Growth hormone (GH) and leptin regulate body composition and leptin is elevated in adult growth hormone deficiency (AGHD), a syndrome characterised by increased adiposity. We have previously shown that GH replacement for 1 month reduces 24-h mean leptin concentration independent of changes in fat mass. The long tem effects of GHR on leptin have not been described.24-h mean total leptin concentration was measured using half-hourly blood sampling, to accou...

Aims/objectives: The aim of this retrospective audit on MANAGEMENT OF ACUTE CHARCOT ARTHROPATHY was to assess the current practice at King’s Mill hospital against the latest National institute of clinical excellence guidelines.Methods: A retrospective audit of 22 patients with diabetes presented with acute Charcot neuro-arthropathy, between January 2016 and August 2018 to the specialist diabetes foot team at KMH. The data was collected from the hosp...